Summary:
Indication
Calcium and vitamin D deficiency, Calcium and vitamin D supplement, Osteoporosis.
Administration
Should be taken with food.
Adult Dose
Oral Adult 1 -2 tablets per day, preferably one tablet each morning and evening.
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Contraindication
Hypercalcemia and hyperparathyroidism Hypercalciuria and nephrolithiasis Hypersensitivity to the component of this preparation Severe renal insufficiencies
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Mode of Action
Calcium /vitamin D3 prevents or treats negative Ca balance. It also helps facilitate nerve and muscle performance as well as normal cardiac function. Bone mineral component; cofoactor in enzymatic reactions, essential for neurotransmission, muscle contraction, and many signal transduction pathways. Vitamin D3 is a fat-soluble sterol. It is necessary for the regulation and regulation of calcium and phosphate homoeostasis and bone mineralisation. Vitamin D is also essential for healthy bones as it aids in Calcium absorption from the GI tract. In addition to this it stimulates bone formation. Clinical studies also show that Calcium and Vitamin D has synergistic effects on bone growth as well as in Osteoporosis and fracture prevention.
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Precaution
When hypercalcemia occurs discontinuation of the drug is usually sufficient to return serum calcium concentrations to normal. Calcium salts should be used cautiously in patients with sarcoidosis, renal or cardiac disease and in patients receiving cardiac glycosides. Patients with a history of stone formation should also be recommended to increase their fluid intake. Lactation: Distributed in human breast milk Supplement calcium and vitamin D during pregnancy and lactation according to recommended daily allowance
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Side Effect
Calcium Anorexia,Constipation,Flatulence,Nausea,Vomiting,Hypercalcemia,Hypophosphatemia,Xerostomia,Acid rebound,Milk-alkali syndrome Vitamin D Hypercalcemia,Muscle/bone pain,Metallic taste,Headache,Nausea,Vomiting,Dry mouth,Constipation,Arrhythmias
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Pregnancy Category Note
This is safe to take during pregnancy at the recommended doses. However, during pregnancy the daily dose should not exceed 1500 mg of calcium and 600 IU of vitamin D. Animal studies have shown toxic effects on reproduction at high doses of vitamin D. In pregnant women, all calcium or vitamin D overdoses must be avoided as prolonged hypercalcaemia in pregnancy may lead to retardation of physical and mental development, supravalvular aortic stenosis and retinopathy in the child. There are no indications that Vitamin D3 at therapeutic doses is teratogenic in human.
Interaction
May affect the absorption of tetracycline when used together. Concurrent use with systemic corticosteroids may reduce calcium absorption. Thiazide diuretics may decrease urinary excretion of calcium. Concurrent use with ion-exchange resins may reduce GI absorption of vitamin D. Hypercalcaemia may increase the toxicity of cardiac glycosides during treatment with calcium and vitamin D, monitor ECG and serum calcium levels. Bisphosphonate or sodium fluoride should be given at least 3 hr before calcium-containing preparations.
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